Enhancing breakpoint resolution with deep segmentation model: A general refinement method for read-depth based structural variant callers
Fig 4
Comparison of the enhanced RD-based SV callers with two different SV callers on the simulated data.
Evaluated SVs are the ones that overlap with the gold-standard SVs (Jaccard similarity > 0.5). SVs with exact breakpoints (both-boundary-match, which is abbreviated as “*_exact”) predicted by CNVnator (w/wo enhancement) are compared with the GS-ov SVs predicted by Delly and Lumpy, which are shown in the following Venn diagrams. Any two predicted SVs are treated as overlapped as long as they overlap with the same gold-standard SV. The Venn diagrams were plotted using Eulerr [20]. (A) Comparison of CNVnator (w/wo enhancement) and Delly. (B) Comparison of CNVnator (w/wo enhancement) and Lumpy.