Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model
Fig 6
Cardiac electrophysiological properties and lidocaine binding.
(A) APD90 restitution curve for our modified ten Tusscher et al. model with 20 μM of lidocaine (blue curve) and a steeper, hypothetical restitution curve (black circles). (B) Time course of transmembrane potential for our modified ten Tusscher et al. model paced at a BCL of 750 ms and the square wave approximation of V (dashed blue line) as well as hypothetical alterations: VAP decreased to -20 mV (dashed yellow curve), VDI decreased to -95 mV (dashed purple curve), and VDI increased to -75 mV (dashed orange curve). (C) Fraction of channels bound to lidocaine during the upstroke (b*(BCL)) in the presence of 20 μM lidocaine, as given by Eq (5), for our modified ten Tusscher et al. model and the various shifts in cardiac electrophysiological characteristics in (A) and (B).