Robustness of neuronal tuning to binaural sound localization cues against age-related loss of inhibitory synaptic inputs
Fig 5
Simulated effects of inhibition loss on binaural phase tuning of LSO.
A-D. Responses of the model LSO neuron to 150-Hz amplitude-modulated sounds. E-H. Responses of the model LSO neuron to 450-Hz amplitude-modulated sounds. Panels A, B, E and F present simulated envelope phase-tuning curves for different numbers of inhibitory inputs either without (A,E) or with (B,F) amplitude compensation. The color code used is the same as in Figs 2–4. Thin lines in C and G show peak (max) and trough (min) rates of the corresponding phase-tuning curves in B and F, respectively. Thick solid lines in C and G show the modulation depth defined as the difference between maximum and minimum rates for the compensated case, while gray dot-dashed lines show that for the uncompensated case. D and H present the neuronal discriminability of envelope phase-tuning curves averaged over the range between -180 and +180 degrees and normalized to the value for 8 inhibitory inputs either for the compensated case (solid black) or uncompensated case (dot-dashed gray).