De novo mutational signature discovery in tumor genomes using SparseSignatures
Fig 4
A) The 8 mutational signatures obtained by applying SparseSignatures to a dataset of 560 breast tumors. We report the number and correlation of the most similar (correlation higher than 0.70) corresponding signature from COSMIC (https://cancer.sanger.ac.uk/cosmic/signatures). Source data are provided in S23 Table. B) Boxplots showing fitted values for exposure to each of the 8 signatures obtained by SparseSignatures for BRCA1/2-mutated and non-mutated tumors. Boxplots represent the fraction of mutations per tumor (on the y-axis) contributed by the given signature (on the x-axis). Source data are provided in S24 Table.