De novo mutational signature discovery in tumor genomes using SparseSignatures
Fig 1
A) Schematic of the SparseSignatures method. N represents the number of tumors in the dataset, K the number of signatures. B) Background signature derived from COSMIC SBS5. C) Background signature derived from the human germline mutation spectrum. Vertical bars represent the probability of mutation in each of 96 categories. These are based on 6 possible mutation types (upper gray labels) and 16 possible combinations of 5’ and 3’ flanking bases (x-axis labels). Source data are provided in S1 Table.