From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology
Fig 4
A: Time dependence of HV for the dynamic model with or without additional AD pathology. An HV of 1 is maximal. At age 75, the annual changes in hippocampal volume are −0.015% (static model, not shown), −0.29% (dynamic model), and −1.1% (AD pathology model—rates have been scaled to match this value). The HV ratio between those at age 71.6 (AD pathology) to age 63.4 (CN) is 0.859. We can also compare within models. The hippocampal volume ratios between age 71.6 to age 63.4 years are as follows: 0.999 (static), 0.984 (dynamic), and 0.944 (AD pathology). B: Traumatic Brain Injury. Our fit to clinical data [56] for the relative hazard rate vs number of TBIs, n. The error bars represent one standard error. Model fit:
with
to be estimated. The fitted value is a = 0.231.