From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology
Fig 3
Comparison of static and dynamic models with clinical data for AD. The dotted green lines represent the line of best fit to clinical data [19, 34] on log-scale; The black solid lines are the lines of best fit to the dynamic model on log-scale. A: for prevalence, the clinical doubling time is 4.9 y and our dynamic model predicts 12 y. B: for incidence, the clinical doubling time is 4.9 y and our dynamic model predicts 11 y. The value γ is chosen so that clinical and dynamic model incidence agree at age 60.