Integration of a physiologically-based pharmacokinetic model with a whole-body, organ-resolved genome-scale model for characterization of ethanol and acetaldehyde metabolism
Fig 3
Effect of ingested ethanol concentration on absorption kinetics.
Our combined model fitted to data from Mitchell et al [47]. We varied absorption (kStom, kSI) and transport (kStomSI) parameters in the PBPK model with a Vmax of 1.5mM/min to fit the data for beverages with concentrations of 20%, 12.5%, and 5.1% by a group of men with an average age of 37.8, mass of 82.66 kg, height of 177.1 cm and body fat of 20% drinking 0.5g ethanol/kg. The inset Fig shows the AUC0-∞ for the different ethanol percentages based on the model prediction.