Pathway analysis in metabolomics: Recommendations for the use of over-representation analysis
Fig 6
The effect of assay chemical specificity on pathways accessible in the KEGG metabolic network.
Both figures a and b are based on the four assay types present in the Stevens et al. dataset. The colours in each subfigure correspond to the four assay types shown in the legend. A) KEGG reference metabolic network with compounds from each assay type highlighted on their respective pathways. KEGG network annotated using iPath 3 [22]. B) Venn diagram showing the number of KEGG pathways accessible using the compounds in each of the four assay types. Numbers outside the Venn diagram indicate the total number of pathways accessible with each assay type. Venn created using InteractiVenn [23].