Pathway analysis in metabolomics: Recommendations for the use of over-representation analysis
Fig 4
Comparison of pathway databases and database updates.
A) Pathway size distribution of KEGG, Reactome, and HumanCyc databases. Violin plots show the distribution of pathway size (number of compounds, log10 transformed). Bold vertical lines show median, dashed vertical lines show lower and upper quartiles. B) Comparison of Reactome human pathway set (R-HSA) releases spanning the years 2017 (R61, June 2017) to 2020 (R75, December 2020). Data for release 67 was not available. Dot colour corresponds to release version, with lighter colours representing newer releases.