Pathway analysis in metabolomics: Recommendations for the use of over-representation analysis
Fig 1
Over Representation Analysis (ORA).
Venn diagram representing ORA parameters corresponding to Eq 1. N represents compounds forming the background set, which covers part of the full metabolome. M represents compounds in the pathway of interest. n represents compounds of interest (i.e., differentially abundant metabolites), and k represents the overlap between the list of compounds of interest and compounds in the pathway.