Quantification of long-term doxorubicin response dynamics in breast cancer cell lines to direct treatment schedules
Fig 6
Examples of model fitting demonstrate the ability of model 1 to capture long term dynamics.
Examples of model fitting are shown for a single replicate culture in the MCF7 (A), BT474 (B), and MDA-MB-231 (C) cell lines. The curve represents a response to the doxorubicin concentration used in serial treatment within the cell line– 75 nM for the MCF7 line, 35 nM for the BT474 cell line, and 200 nM for the MDA-MB-231 cell line. Data is shown as open blue circles, while the best-fit curve for model 1 (the total number of sensitive and resistant cells) is shown in black, with the resistant and sensitive compartments shown in red and green respectively.