Quantification of long-term doxorubicin response dynamics in breast cancer cell lines to direct treatment schedules
Fig 2
Micrograph example illustrating doxorubicin induced proliferation delay.
In this example demonstrating a doxorubicin induced proliferation delay, after exposure to 150 nM doxorubicin at time 0 (A) MCF7 cells stop proliferating and remain in arrest for 315 hours. At 14 days (B), cells have died off in the intervening time, and proliferation has not occurred, and at 21 days (C), proliferation has produced a small patch of cells indicated by the red arrow; proliferation then continues and produces a patch of hundreds of cells by 28 days (D). Untreated cells grow to confluence in approximately four days.