Multiscale modeling of tumor growth and angiogenesis: Evaluation of tumor-targeted therapy
Fig 3
Boolean model prediction of cell phenotype (state) for various input configurations.
Colors correspond to the color of the nodes in Fig 2, indicating activity of the receptors’ signal (i.e. integrin, RTK, Wnt) and inactivation of receptor is shown in grey. Tumor suppressors are deactivated. For instance, if the cell receives a signal from integrin and RTK, and no signal from Wnt (110), considering cadherin activation, the model predicts that the cell starts to grow and proliferate (1100). The binary code on the first row specify the integrin, RTK and Wnt states, respectively.