Multiscale modeling of tumor growth and angiogenesis: Evaluation of tumor-targeted therapy
Fig 2
Signaling networks considered in the model that are involved in tumor growth; the implemented network focuses on Ras- PI3K-Akt and Wnt/ß-catenin signaling that control the cancer cell state.
Highlighting the relationship between external stimuli, Wnt, RTK, cadherin and integrin, the cell can be growing, proliferating, migrating or undergoing apoptosis. A pointed head arrow indicates activation whereas a blunt head refers to inhibition.