Optimizing mitochondrial maintenance in extended neuronal projections
Fig 10
Optimal performance of mitochondrial maintenance models in presence of mitophagy.
(a) For each mitophagy threshold ϕ, the parameters fs, Ns are optimized to give the maximum normalized average health: 〈H〉. The resulting normalized average health (blue) and normalized last region health (yellow) are plotted for the CoG model (solid) and SS model (dashed). (b) Analogous plots, with parameters adjusted to maximize the normalized last region health for each mitophagy threshold. All health levels are normalized by total mitochondrial content per region (M/n), corresponding to a system where the total amount of mitochondrial material is limited. Error bars show standard error of the mean from 10 replicates. Fixed parameters are
, M = 300, n = 10. A corresponding plot of optimized health for low decay rate
is provided in S5 Fig.