Optimizing mitochondrial maintenance in extended neuronal projections
Fig 9
Effect of mitophagy when total mitochondrial number is limited.
(a) Fraction of mitochondria in the stationary state as a function of increasing mitophagy threshold, for the CoG model (solid line) and the SS model (dashed line), with parameters set such that fs = 0.53 at ϕ = 0. (b) Mitochondrial health, normalized by the total number of mitochondria per site, averaged over all demand sites, for the CoG model. (c) Normalized mitochondrial health at most distal demand site, for the CoG model. (d-e) Analogous plots of normalized average health and distal site health for the SS model. Normalizing by total mitochondrial number is equivalent to a system where the total mitochondrial content is held fixed with the onset of mitophagy (S4 Fig).