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Optimizing mitochondrial maintenance in extended neuronal projections
Fig 6
Mitochondrial health in the presence of local translation.
(a) Average health across all demand regions as a function of fraction of stopped mitochondria (fs) and number of stopping events (Ns), for high decay rate (
) and local translation level α = 10%. Markers show the optimal parameter values with (red asterisk) and without (blue circle) local translation. (b) Corresponding mitochondrial health at the most distal demand site. (c) Enhancement of health levels at each demand site in the presence (Hi,t) versus absence (Hi) of local translation, for one set of transport parameters, (fs = 0.5, Ns = 0.4), two decay rates 
, and three different local translation levels (α).
doi: https://doi.org/10.1371/journal.pcbi.1009073.g006