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Optimizing mitochondrial maintenance in extended neuronal projections

Fig 5

Optimizing mitochondrial health through variation of transport parameters.

(a-b) Average health across all demand regions as a function of fraction of stopped mitochondria (f_s) and number of stopping events (N_s), for two dimensionless decay rates (). (c-d) Mitochondrial health at the most distal demand site, for two different decay rates. (e-f) Values of the f_s and N_s parameters that correspond to maximum average health (blue curves) or last region health (yellow curves). Optimal parameters are plotted as a function of the decay rate. Results shown were computed for the CoG model.

doi: https://doi.org/10.1371/journal.pcbi.1009073.g005