Optimizing mitochondrial maintenance in extended neuronal projections
Fig 4
Mitochondrial health as a function of key dimensionless parameters.
Solid curves show normalized average health over all demand sites; dashed curves show normalized health at the most distal site. The number of demand sites is set to n = 30 (blue) or n = 100 (magenta). For each fraction of stationary mitochondria the fusion probability is adjusted to give a fixed number of stopping events for an individual protein traversing the domain: (a) Ns = 2 and (b) Ns = 20. All values shown are for the SS model, with M = 1600 and . Results for different values of M are provided in S2 Fig.