Optimizing mitochondrial maintenance in extended neuronal projections
Fig 2
Comparison of mean-field and discrete stochastic models.
(a) Snapshot of stochastic simulation of the CoG model, with M = 100. (b) Steady-state solution for mitochondrial health in the CoG model (Eq 2). Solid curves show linear density of mitochondrial health in anterograde (blue) and retrograde (magenta) mitochondria, normalized by total number of mitochondria in the domain. Yellow circles show total health at each of the discrete demand sites (dashed black lines), normalized by the total number of mitochondria per region. Shaded regions show corresponding quantities from discrete stochastic simulations (mean ± standard deviation) with M = 1500 mitochondria in the domain. Parameters used in (a) and (b): n = 5, ps = 0.4, fs = 0.5, kd L/v = 0.6. Corresponding results for the SS model are provided in S1 Fig.