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Statistical tests for intra-tumour clonal co-occurrence and exclusivity

Fig 7

Significance of clonal co-occurrence or exclusivity of the three GeneAccord tests for the AML cohort.

For the AML cohort, we plot the significance of clonal co-occurrence or exclusivity by computing the log₁₀ p-value and including the sign of the effect (positive indicating clonal co-occurrence, negative indicating clonal exclusivity) for the three geneAccord tests: The x-axis depicts the placement test, the y-axis the occurrence test and the colouring the combined test (red indicating clonal co-occurrence, blue indicating clonal exclusivity). The labels of the significant gene pairs of the combined test, after Benjamini-Hochberg correction (Table 1), are also coloured.

doi: https://doi.org/10.1371/journal.pcbi.1009036.g007