Statistical tests for intra-tumour clonal co-occurrence and exclusivity
Fig 6
Comparison to standard exclusivity tests.
Standard independence tests (top row: Fisher’s exact test, G-test and log odds ratio (OR) test, from left to right) are heavily miscalibrated for data generated from placing mutations on lineage trees under the null. GeneAccord’s gene pair placement test (bottom row: chi-squared approximation, exact test and with Monte Carlo smoothing, from left to right), apart from some enrichment with the chi-squared approximation, shows proper calibration.