Ion dynamics at the energy-deprived tripartite synapse
Fig 8
Experimental findings from Brisson and Andrew [32] (reproduced with permission) and our model simulations.
(A) (Left) Membrane depolarization of a pyramidal neuron during 10 minutes of oxygen glucose deprivation (OGD), that persists after restoring energy. (Right) Model simulations on the right show the neuronal (blue) and astrocyte membrane potentials. ED (OGD) is introduced for 15 minutes (red line). Here, αe = 80% and Pmin = 0%. The dynamics are faithfully reproduced, including anoxic oscillations at the initial phase of depolarization. (B) (Left) Membrane potential of a magnocellular neuroendocrine cell, showing a similar depolarization during 15 minutes oxygen glucose deprivation and full recovery after this period. Both at the start of the depolarization and during recovery action potentials are generated. (Right) Model simulations. ED (OGD) is introduced for 15 minutes (black line). Here, αe = 80%, Pmin = 0% and Pscale = 2. With these parameter settings, the membrane potential recovers to baseline conditions after the period with ED. Note that during recovery, the experimentally observed oscillations are also faithfully simulated.