Ion dynamics at the energy-deprived tripartite synapse
Fig 6
Differential sensitivity of ED to initial extracellular volume ratio αe (A) and to baseline Na+/K+-ATPase strength factor Pscale (B).
(A) We deprive the neuron and astrocyte of energy for 5 minutes before restoring it to baseline and report the relative volume 30 minutes after restoration. We show two examples, (A.1) for large ECS (αe = 80%) and (A.2) for realistic ECS (αe = 20%). Here, we plot neuronal (blue), astrocyte (orange) and extracellular (green) traces against time for compartmental volume change. (B) We deprive the neuron and astrocyte of energy for 15 minutes before restoring it to baseline, for two different values of Pscale and αe. We show neuronal and astrocyte membrane potentials against time. The grey area in (B.1–4) illustrates the period of ED. The table in the middle indicates whether the system recovers (green) post energy restoration or not (red).