Ion dynamics at the energy-deprived tripartite synapse
Fig 5
ED for 5 minutes (A) and 15 minutes (B) demonstrates the existence of two stable states: 1) before ED (baseline resting state) and 2) after prolonged ED of 15 minutes (stable depolarized state).
Here, we plot neuronal (blue), astrocyte (orange) and extracellular (green) traces against time for several quantities. The initial extracellular volume ratio αe = 80% and minimal energy available Pmin = 50%. Shaded grey areas correspond to the period where Na+/K+-ATPase (NKA) activity is gradually reduced to Pmin and restored to baseline, identical to Fig 3A.