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Ion dynamics at the energy-deprived tripartite synapse

Fig 3

Model calibrations reproduce experimental data.

(A) Plot of versus time t. ED begins at t = t_start min. and ends at t = t_end min. while being reduced to a minimum of P_min. (B,C) Experimental traces from [8] (left) and the corresponding model simulations (right) with (B) showing intracellular sodium for neurons and astrocytes and (C) showing extracellular sodium and potassium. Empirically adjusted parameters: P_min and (initial extracellular volume fraction) were chosen by fitting model dynamics qualitatively to Na⁺ and K⁺ concentration time-traces. Here, P_min = 50% and . The difference in Na⁺ increase between neurons and astrocytes is attributed to the presence of fast Na⁺ influx through voltage-gated Na⁺ channels in neurons, which are lacking in astrocytes. Please note that scaling axis in panels B and C may slightly differ between experiments and simulations for optimal display purposes.

doi: https://doi.org/10.1371/journal.pcbi.1009019.g003