Performance assessment of sample-specific network control methods for bulk and single-cell biological data analysis
Fig 4
Evaluation of SSC workflows for drug target identification on LUSC and LUAD cancer datasets from TCGA.
To evaluate the usage efficiency of sample-specific network drivers for personalized drug target discovery, the number of targeted sample-specific network drivers matching with drug combinations are calculated and anti-cancer drug target combinations are ranked for each patient. The drug combinations annotated in the Clinical Anti-cancer Combinational drugs (CAC) were applied to assess the AUC of the top-ranked/predicted anti-cancer drug combinations from different SSC workflows using (A) LUSC and (B) LUAD cancer datasets.