Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma
Table 1
Parameter estimates are based on posterior samples obtained via Markov Chain Monte Carlo (MCMC) using random uniform prior distributions with boundaries that were well outside the obtained 95% confidence regions.
For sampling, we used a multivariate Metropolis-Hastings algorithm with >100, 000 samples for Males and >200, 000 samples for Females. The marginal medians listed in this table agreed well with the obtained maximum likelihood estimates and led to very similar incidence predictions (S3 Fig).