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Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma

Fig 4

ESCC incidence (data, black shapes; model fits, black lines) by sex, race and age group as indicated from 1975-2016.

For comparison, non-parametric fits using 4^th-order smoothing splines are shown in red.

doi: https://doi.org/10.1371/journal.pcbi.1008961.g004