Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma
Fig 3
A) Two-hit process for the initiation of dysplastic clones; B) Sporadic formation of field-defect followed by single hit process for the initiation of dysplastic clones. Note, only the product is identifiable and represents the rate at which dysplastic clones are initiated in the defective field.