A model of dopamine and serotonin-kynurenine metabolism in cortisolemia: Implications for depression
Fig 3
Notable changes in key dependent variables in response to cortisolemia and treatment.
(A) Two-fold increase in the activity of VMAT2. (B) 95% Inhibition of the transporter SERT. (C) 50% Inhibition of the activity of enzyme KMO. (D) Combined inhibition of SERT (↓95%) and KMO (↓50%). Time courses are shown on the left and percent changes after treatment on the right of each panel. CORT is increased by 50% at day 8 and “treatment” starts at day 25 (black triangles).