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A model of dopamine and serotonin-kynurenine metabolism in cortisolemia: Implications for depression

Fig 2

New steady-state values of dependent variables in response to a 50% increase in CORT.

The percent changes were calculated in comparison to the corresponding values under control conditions (CORT at baseline of 100%). Also shown are the ratios QUIN/KYNA and KYNA/3-HK, which reflect the balance between levels of key metabolites.

Fig 2

doi: https://doi.org/10.1371/journal.pcbi.1008956.g002