Systematic comparison and prediction of the effects of missense mutations on protein-DNA and protein-RNA interactions
Fig 2
Comparison of binding affinity changes induced by MPDs and MPRs.
(A) Overall comparison of MPDs and MPRs. (B) Comparison of MPDs and MPRs based on residue types. The numbers of mutations are shown in the columns. (C) Distribution of MPDs and MPRs in different geometric locations. (D) Comparison of MPDs and MPRs based on geometric locations. (E) Distances between different mutation groups. (F) Comparison of MPDs and MPRs interacting with major or minor grooves. (G-I) Comparison of MPDs and MPRs based on their major binding modes (i.e., the major interacting nucleotides (G), the major interacting subunits of nucleotides (H), and the major interacting contacts between the target residue and nucleotides (I)). For example, the major interacting nucleotides represent that the atomic contacts between a specific type of nucleotides and the target residue account for the greatest proportion among all contacts involving this residue. *** P<0.001, ** 0.001≤ P<0.01, and * 0.01≤ P<0.05.