Efficient representations of tumor diversity with paired DNA-RNA aberrations
Fig 2
Networks of pair coverings in breast cancer.
The network shown in the center depicts one covering of breast cancer samples by STPs, with source genes in orange, target genes in blue, and intermediary link genes in green. The thin and thick edges represent, respectively, the two types of relationships: “controls state change of” and “controls expression of” as designated in Reactome [19]. On the left are presented a selection of covering realizations for three ER-positive samples, where aberrant STPs are highlighted, while and on the right, three ER-negative samples samples are shown. The samples have different realizations over the covering network, and are ranked (top to bottom) by the number of events they exhibit. The sample networks demonstrate the inter-sample heterogeneity among the source and target realizations.