The landscape of metabolic pathway dependencies in cancer cell lines
Fig 4
Metabolic pathway activity identifies anti-cancer drug sensitivity independent of cell culture medium.
A) Schematic representing the strategy used to integrate metabolic pathway activity with drug response screens. Cancer cell lines were separately processed by culture type and culture medium with a focus on adherent cell lines. All correlation p-values were FDR corrected using a Benjamini-Hochberg correction. B-E) Scatter plots of significant drug:metabolic pathway combinations (FDR < 0.05) in both DMEM and RPMI mediums. Correlation coefficients and FDR corrected p-values are shown for each correlation. The annotated gene target of each drug is listed below the drug name. The remaining significant associations are listed in S2 Table.