The metastable brain associated with autistic-like traits of typically developing individuals
Fig 1
The dynamic PPC-PAC hypothesis.
(A) A repertoire of synchronous slow oscillations that interact via the PPC and interact with fast oscillations via the PAC. (B) The resulting PAC states. (C) Transitions between the metastable PAC states. The dynamic PPC-PAC hypothesis states that for the resting brain, dynamic changes in PPC strengths (transitions between synchronous states) can cause dynamic and large-scale changes in PAC strengths because of PPC-PAC connectivity (A), and thereby yield transitions between oscillatory states with multiple peak frequencies (B and C). The oscillations of each state can realize the transition to another state by spontaneous fluctuations in the brain; in other words, the underlying states can show metastability.