Ranking microbial metabolomic and genomic links in the NPLinker framework using complementary scoring functions
Fig 7
Scores starting from particular GCF.
Position of the score for the validated GCF-MF pair (red) within the distribution of the scores of the links between that particular GCF and all MFs, for a selection of validated links in the Crüsemann data set (rows). The first three columns show histograms of the raw and standardised versions of the strain correlation score, as well as the IOKR score, for all links including a given GCF, with the score of the correct link indicated. The last column shows the standardised correlation score (x-axis) and IOKR score (y-axis) for the same links, again with the correct link indicated. Both IOKR and the standardised correlation scores tend to put validated links higher in the distribution of scores for the GCF in consideration, than the raw correlation score. Furthermore, some of the validated links score relatively higher on IOKR than the standardised strain correlation score, and vice versa, suggesting that the two scores complement one another. For full results, as well as for other data sets, please refer to S4 Fig.