A novel yeast hybrid modeling framework integrating Boolean and enzyme-constrained networks enables exploration of the interplay between signaling and metabolism
Fig 4
The core reactions in the metabolism under (A) respiration and (B) fermentation are shown. The fluxes are represented by the width of the connectors where dotted lines represent zero flux. The color of the connectors represents the change in flux from the unregulated ecModel compared to the regulated hybrid model. The FCCs are represented in the figure where the unregulated case is depicted by circles and compared to the regulated case depicted in squares.