A novel yeast hybrid modeling framework integrating Boolean and enzyme-constrained networks enables exploration of the interplay between signaling and metabolism
Fig 3
(A) Absolute log10-transformed ratio between predicted and measured protein abundance values in respiration and fermentation for the purely enzyme-constrained and hybrid models. (B) Evaluation of isoenzymes utilization predictions, comparing the ecModel and hybrid model on respiratory and fermentative conditions against experimental data on protein expression (absence/presence). FMI—Fowlkes-Mallows index. (C) Comparison of individual isoenzymes utilization between models’ predictions and experimental data. Color indicates presence or absence of a given protein in the predictions of the ecModel, hybrid model and experimental data on protein expression.