CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation
Fig 6
The results of running a pure zero-dimensional simulation of the model shown in Fig 5.
Note the differing y-axis scales. Panel A: Case C1—the time evolution of the myocardial hunger in the left anterior descending (LAD) perfusion territory of the myocardium, in the patient-specific simulation under baseline resting conditions. The blood supply is such that the hunger is kept close to zero for the entire simulation. Panel B: Case C2—the model with parameters perturbed to simulate PRS. The hunger grows continually, indicating that the blood supply to this perfusion territory is insufficient, and thus, myocardial ischaemia.