High-affinity P2Y2 and low-affinity P2X7 receptor interaction modulates ATP-mediated calcium signaling in murine osteoblasts
Fig 4
Comparison of simulated and experimental dynamics of ATP-induced [Ca2+]i responses.
(A) Time series simulations of [Ca2+]i responses generated by the complete model of P2Y2 and P2X7 (full model, blue), P2X7 submodel (grey) and P2Y2 submodel (yellow). Parameter values are provided in Table 1. (B) Experimental recordings of [Ca2+]i responses in WT (blue), P2ry2Δ (grey) and P2rx7Δ (yellow) C2-OB cells in response to varying [ATP].