Apoptosis mapping in space and time of 3D tumor ecosystems reveals transmissibility of cytotoxic cancer death
Fig 6
The Potential of death induction (Pdeath) of cancer cells increases over time upon cytotoxic death, but not upon natural death.
A. Representative Pdeath analysis on one video of breast cancer MDA-MB-231 cells cultured within ToC without (left, natural death) or with 1 μM doxorubicin (right, cytotoxic death). B. Representative Pdeath analysis on one video of NSCLC IGR-Pub cells cultured within ToC alone (left, natural death) or together with autologous CTL (P62 clone) (right, cytotoxic death). C. Representative Pdeath analysis on one video of breast cancer MDA-MB-231 cells co-cultured with CAFs within ToC, without (left) or with 1 μM doxorubicin (right). More video analyses on additional view fields are shown in S2 Fig.