Hypoxic pulmonary vasoconstriction as a regulator of alveolar-capillary oxygen flux: A computational model of ventilation-perfusion matching
Fig 10
Effect of airway occlusions on HPV-mediated redistributions in hemodynamics, V/Q matching, and oxygen flux.
(A-C) Leftmost column of networks are with 0% of the alveoli occluded, middle column of networks are with 17% of the alveoli occluded, and the rightmost column of networks are with 28% of the alveoli occluded. The first airway occlusion is at the most southwestern perfusion zone, and progressive airway occlusions are made following the structure of the vascular network. The black scale bar is 1000 μm. (A) Perfusion in the capillary compartment; (B) Ventilation-Perfusion (V/Q) ratios in the capillary compartment; (C) Oxygen flux in the capillary compartments; (D) End-venous oxygen tension as a function of the fraction of occluded alveoli; (E); Pearson correlation between ventilation and perfusion as a function of the fraction of occluded alveoli; (F) Coefficient of Variation for blood flow (circles), V/Q ratios (x’s), and oxygen flux (squares); (G) Distribution of blood flow; (H) Distribution of V/Q ratios; (G) Distribution of oxygen flux.