Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection
Fig 5
The pipeline for GS-DFA beginning from RNA-seq of infected and normal cell line, followed by construction of context specific models, flux sampling, reaction filtering and over-representation analysis of pathways.
The ‘star’ symbol indicates a multiple hypothesis correction step through Benjamini-Hochberg False Discovery Rate. A two-sample Kolmogorov-Smirnov test is used to differentiate between the probability distribution of flux between diseased and non-diseased state.