Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection
Fig 4
Boolean relation between activity of enzymes and the gene encoding the proteins in the complex makes the prediction of flux from expression difficult.
Gene A and Gene B encodes subunits of the enzyme which catalyzes ‘Reaction 1’. Gene C and Gene D encode two alternative isozymes which catalyzes ‘Reaction 2’. The width of the arrow for ‘Reaction 1’ and ‘Reactions 2’ represents the level of flux. The black arrow is in the direction of cause to effect. A fold change in the expression of A is sufficient to change the flux through reaction 1 which further changes through reaction 2. All the enzymes are assumed to have their concentration above the threshold. (Created with BioRender.com).