Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection
Fig 3
(A) and (B) show the metabolic condition for low and high arginine uptake rates respectively. A high arginine uptake increases the flux through NOS (Nitric Oxide Synthase) pathway which scavenges oxygen away from aerobic metabolism and impairs viral growth. (C) and (D) show the metabolic states for high and low lysine uptake. A low lysine uptake reduces the flux through lysine degradation pathway (Saccharopine pathway) and reduces the supply for Acetyl-CoA required for viral growth. (E) The robustness of specific growth rate of SARS-CoV-2 with respect to changes in specific uptake rates of arginine and lysine. Refer to S3 Fig for robustness analysis with respect to specific uptake rates of all nutrients. Fig 3A–3D were created using BioRender.com.