Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection
Fig 2
Generation of context-specific models of SARS-CoV-2 infected cells and normal cells using gene-expression data and tINIT algorithm.
(A) The distribution of TPM normalized gene expression in Mock NHBE cells, SARS-CoV-2 infected NHBE cells, Normal Lung Tissue (From Biopsy) and Infected Tissue (From Biopsy). (B) The Hamming distance between all the generated context specific models based on the differences in reactions in the model. (C) The pathways over-represented while comparison between models. The reactions over-represented in each comparison are present exclusively in one of the models. (D) The agreement of model simulated specific growth rate of the virus with the experimental reported specific growth rate. n.s. stands for non-significant differences as estimated by t-test. The model simulated growth rate was calculated under ±5% uncertainty in biomass composition and uptake rates. The experimental growth rates were derived from Bojkova et al. (Nature), 2020.