A computational study of co-inhibitory immune complex assembly at the interface between T cells and antigen presenting cells
Fig 7
We have performed a computational experiment in the cis-interactions between B7 and PD-L1 was turn on and off in two separate simulation scenarios.
We collected the numbers of different interactions along the last 2×106ns of both simulation trajectories. Their distributions are compared with each other as box-whisker plots in (A), (B), (C), and (D). The boxes in these plots give the range from 25 to 75 percentiles for the number of interactions, while their average number of interactions is marked in the middle of each box. The whisker indicates the outlier of the distribution with the coefficient equal 1.5. The type of interactions is indicated on top of each plot. The system with cis-interaction (WT) is shown by green boxes, while the system without cis-interaction (MT) is shown by red boxes. Finally, the close-up view of the largest cluster formed in the final configuration of the MT scenario is shown in (E), and the close-up view of the largest cluster formed in the final configuration of the WT scenario is shown in (F).