A computational study of co-inhibitory immune complex assembly at the interface between T cells and antigen presenting cells
Fig 5
The kinetic profiles are compared between two selected systems.
The changes of B7/PD-L1 cis-interactions as a function of simulation time were plotted in (A). The changes of B7 dimers as a function of simulation time were plotted in (B). The changes of CTLA-4/B7 trans-interactions as a function of simulation time were plotted in (C). The system with strong cis-binding affinity of -13kT is represented by red curves, while the system with weak cis-binding affinity of -3kT is represented by black curves. Finally, the final configurations from these two comparing systems were plotted. The configuration with strong affinity is shown in (D) and the configuration with weak affinity is shown in (E), respectively.